Developing a Compensator using Cerrobend Materials

Developing a Compensator using Cerrobend Materials ABSTRACT In external beam radiotherapy (EBRT), dose optimization is achieved by conforming the dose distribution to the shape of the intended target whilst minimizing radiation to normal tissues in close proximity to the target. This is achieved by modulating the intensities of the radiation across the radiation portals forming the irradiation geometry used for the treatment. Compensators may be used to achieve the above effect and can be used to approximate the fluence map by appropriate linear attenuation coefficient of individual beamlets making up the original open beam fluence. This may be done with a treatment planning system (TPS) with inverse planning capabilities or with a bolus placed on the surface of the patient at the beam entrance point. This work describe the procedures for designing, constructing and dosimetric considerations of cerrobend compensator for high energy photon beams, using the bolus option on the surface of the phantom planned with Prowess Panther TPS. Also correc tion factors that account with effects of field size, treatment depth and changes in thickness ratio because of using bolus were introduced. The cerrobend compensator was adjusted to account for beam divergence and reduction in dose contributed by scattered radiation. The correction factors were applied to the thickness ratio for determination of appropriate thickness of cerrobend that mimic bolus. The measurements were done in Theratron Equinox 100 cobalt-60 teletherapy unit using Cerrobend slabs constructed to account for divergence of the beam for the maximum field size considered in this research (3030 cm2). The narrow and broad beam linear attenuation coefficient for cerrobend were determined using simple attenuation model, varying the field size from 44 cm2 to 3030 cm2 field sizes in air, and also varying the thickness of cerrobend from 0.5cm to 4.6cm. The value found was 0.4574cm-1 and also the field size dependence of linear attenuation coefficient were investigated. The sca tter produced by cerrobend was accessed and evaluated. The scatter-to-primary ratio dose contribution was found to be negligible for small field size as reported by Dimitriadis (2002), and can cause error in the final dose calculation up to 13.3% for 3030 cm2 and 4.09 cm thickness of cerrobend. The cerrobend compensator was successful designed and constructed. The dosimetric accuracy for constructed cerrobend compensator was found to be deviating with that predicted with Prowess Panther Treatment Planning System with percentage error ranging from 0.365 to 25%, which is associated with limitations in producing precise thickness of cerrobend with the same accuracy of that generated by the equation 3.04 and limitations in generating flat surface topography and also the presence of air bubble in the cerrobend compensator which was not investigated in thiswork. CHAPTER I INTRODUCTION BACKGROUND Cancer is a significant health care problem. On average about half of all cancer patients are treated with radiation therapy worldwide (IAEA, 2004). Radiotherapy, also referred to as radiation therapy, radiation oncology or therapeutic radiology is one of the three modalities used to treat malignant disease (cancer) the other two being chemotherapy and surgery (Suntharalingamn et al, 2005). Radiotherapy uses ionizing radiation to eradicate cancerous cells with the least possible damage to normal tissues. The first therapeutic use of ionizing radiation was demonstrated in 1897 by Wilhelm Alexander Freud, a German surgeon before Vienna Medical Society when he demonstrated the disappearance of a hairy mole following treatment with x-ray (Hall, 2000). The first recorded experiment in radiobiology was also performed by Becquerel when he advertently left a radium container in his vest pocket and subsequently described the skin erythema two weeks later (Hall, 2000). The modalities of radiotherapy are divided into two types, tele-therapy and brachytherapy. Brachytherapy is a method of treatment in which sealed sources are used to deliver radiation at short distances by interstitial, intracavitary or surface application (Khan, 2010). Tele-therapy is a treatment modality in which the source of radiation is at a distance from the patient, also called external beam radiation therapy, it uses photons ranging from kilo voltage to megavoltage photons, and electron beams from linear accelerators or Co-60 tele therapy units. In External Beam Radiation Therapy (EBRT), the methodology of treatment depends on different factors, which may include the shape and size of the tumour to be treated within the patient, sparing of normal tissues within the vicinity of the target from excessive irradiation, financial constraints and the quest of optimization of radiation dose to the target. There are different treatment techniques ranging from 2-D conventional radioth erapy to more advanced Intensity Modulated Radiotherapy (IMRT). IMRT is a treatment planning and delivery technique that can greatly improve the process of conformal radiotherapy which refers to the process of blocking a beam with irregular shaped beam portal so that the dose delivered corresponds more closely to tumour whilst reducing the dose to normal tissue. In developing countries, most of the centrees are restricted to a Co-60 tele therapy unit with basic treatment planning and simulation capabilities. Patients present irregular surface topographies and tissue heterogeneities. According to Chang (2004), a compensator is a traditional tool for modern application and is an alternative IMRT delivery technique. In IMRT, the compensator is used not in the sense of compensating for missing tissue or tissue heterogeneity but as beam intensifier like dynamic wedges and multileaf collimators (MLC). The goal is to achieve dose uniformity throughout the whole target volume and, more importantly to spare critical structures according to the dose and dose volume constraint prescribed by the clinicians for specific patients (Jiango et al, 1998). Therefore, compensators are designed to produce an optimized primary fluency profile at the patient’s surface. This is achieved by modulating the intensities of the radiation across the radiation portals forming the irradiation geometry used for the treatment. There are various methods by which compensators can be made. According to Williams and Thwaites (2000), the three main types are grid-blocking system, contour system and a system using machined compensator. The first compensators made by Ellis et al. (1958) were constructed by stacking aluminum pillars. Another method reported by Lam et al. (1983) describes the construction of compensators from thin sheets of lead. Today compensators are more commonly made from molds filled with molten alloy or wax. Using molds is advantageous since it results in compensators with smoother surfaces and thus greater accuracy. To make a compensator for an IMRT practice, it is required to calculate the effective attenuation coefficient () of its materials, which is affected by various factors as field size, depth, off- axis distance, compensator thickness (Haghparast et al, 2013). A number of elements have been used to form compensators which include tungsten-epoxy mixture (Xu et al, 2002), Lucite (Khan et al, 1970), gypsum (Weeks et al, 1988), tin-wax (Van et al, 1995), tin (Chang et al, 2000), cerrobend (Waltz BJ et al, 1973), steel (Van et al, 1995), aluminum (Ellis et al, 1959), brass (Ellis et al, 1959; Tess, 2014), lead (Leung et al, 1974; Cunnighan et al, 1976; Andrew et al, 1982; Spicka et al, 1988), coper (Tess, 2014). In this study, a cerrobend compensator will be constructed using a simple attenuation model to determine its effective attenuation coefficient. Film and an ionization chamber will be used for dosimetric measurements and for verification of measured dose distribution and compared with those calculated with the PROWESS Panther TPS software at Korle-Bu Teaching Hospital. PROBLEM STATEMENT In external beam radiotherapy (EBRT), dose optimization is achieved by conforming the dose distribution to the shape of the intended target whilst minimizing radiation to normal tissues in close proximity to the target. Most dosimetric measurements are done on flat surface and homogenous medium, however patients surface is highly irregular and internal tissues are heterogeneous. The main aim of radiation therapy is to deliver uniform dose distribution within +7 % and –5 % (ICRU report 50, 1993) of the dose prescription without exceeding the tolerance dose of the critical structure around tumor volume. To achieve this goal, the above irregularities should be corrected. Thus different studies suggested and implemented bolus which is a tissue equivalent material placed at the surface of the patient to compensate the missing tissue. However, this technique doesnt spare the skin beneath the bolus. This is because, the buildup region is in the bolus and Dmax (depth of maximum dose) will be at skin surface. To solve such complications compensators have been introduced by different people on different approaches to correct both surface irregularity and tissue heterogeneity which is now done by using MLC based IMRT. Advanced technological innovations in anatomic and functional imaging modalities (CT, MRI, PET, and US) have led to improved visualization and the delineation of tumour. Radiation treatment planning and delivered techniques have also seen a marked improvement. Intensity modulated radiotherapy (IMRT) provides a high degree of dose conformity to the planning target volume (PTV) and the conformal avoidance of organs at risk. Therefore radiation field is not only geometrically shaped to conform to the outline of the planning target volume at the beams eye view, but is also intensity modulated. The National Centre for Radiotherapy and Nuclear Medicine of Korle-Bu Teaching Hospital (KBTH) presently uses paraffin wax for construction of a compensator and cerrobend for shielding blocks, but there is a need to implement physical compensator based IMRT using materials which are available in the Centre and is inexpensive. This research will focus on design and construction and dosimetric considerations of cerrobend compensators to modulate the intensities of the radiation across the radiation portals forming the irradiation geometry used for the treatment. OBJECTIVES GENERAL OBJECTIVE The general objective of this work is designing and constructing a compensator using cerrobend materials. SPECIFIC OBJECTIVES To clarify the effect of scattered photons generated within the compensator on head scatter factor. To evaluate dosimetric accuracy and dose coverage. To compare and evaluate measured and predicted data. To evaluate the variation of dose distribution by the compensator. SCOPE AND LIMITATION The scope of this thesis is in the area of the IMRT by means of physical compensators specifically using cerrobend which are manually fabricated. In most centres which are practicing IMRT, the construction of the compensator to provide the needed modulation is done by generating a fluency map of the radiation portal needed. This is done with a treatment planning system (TPS) with inverse planning capabilities or with a bolus placed on the surface of the patient at the beam entrance point. The bolus option will be used in this research as currently there is no TPS in the country that can do inverse planning. In this case, the cerrobend compensator will be used to replicate dosimetric effects of the bolus placed on the surface of the patient. According to Jiang et al (1998), the calculation of compensator thickness profile (an optimized primary fluency profile) is straightforward typically using the exponentially attenuation model. With reference to this, the shape of the compensator w ill be adjusted to account for beam divergence and reduction in dose contributed by scattered radiation. Thus the dosimetric considerations is part of the scope of this research. The measurement will be made from a Co-60 tele therapy machine at Korle Bu Teaching Hospital (KBTH). RELEVANCE OF THE PROJECT WORK In radiation oncology, a patient should get the best treatment option as much as possible in order to improve quality of patient care. So the expected results such as correction factors to account for reduction in scatter for using the cerrobend compensator to mimic bolus would have immense contribution to scientific and technical knowledge. From this work, it will be possible to implement IMRT delivering technique at National Centre for Radiotherapy and Nuclear medicine of Korle-Bu Teaching Hospital. The clinical implementation of IMRT technique requires at least two systems (Khan, 2010), which are: treatment planning computer system that can calculate non-uniform fluence maps for multiple beams directed from different directions to maximize dose to target while minimizing dose to critical normal structures. This may be done with a treatment planning system (TPS) with inverse planning capabilities or with a bolus placed on the surface of the patient at the beam entrance point. The s econd one, is a system delivering a non-uniform fluence as planned, so each of these systems must be appropriately tested and commissioned before the actual clinical use. The bolus option will be used in this research as currently there is no TPS in the country that can do inverse planning. The cerrobend compensator will be used to replicate dosimetric effects of the bolus placed on the surface of the patient. Similar research was done using different materials by Teclehaimanot (2014) in which the results were not in the clinically acceptable levels, so with this work we are expecting to reach such clinical levels with deviation less than 5%. Intensity modulated radiotherapy (IMRT) is widely used in clinical applications in developed countries, for the treatment of malignant and non-malignant diseases. This technique uses multiple radiation beams of non-uniform intensities. The beams are modulated to the required intensity maps for delivering highly conformal doses of radiation to the treatment targets, while sparing the adjacent normal tissue structures. This treatment technique has superior dosimetric advantages over 2-dimensional (2D) and conventional 3-dimensional conformal radiotherapy (3DCRT) treatments. It can potentially benefit the patient in three ways. Firstly, by improving conformity with target dose, it can reduce the probability of in-field recurrence. Secondly, by reducing irradiation of normal tissue, it can minimize the degree of morbidity associated with treatment. Finally, by facilitating escalation of dose, it can improve local control (Cheung, 2006). Compensator based IMRT has a lot of advantages over MLC, many literature reported by Taherkhani (2010), report that the penumbra regions created by MLCs are larger than those generated by cerrobend blocks. Compensators provide more consistent dose, impose no limitations on the dose delivery rate, reduce skin surface doses, and because of the high density of the cerrobend allows improved skin sparing with low production rate of secondary electrons (Gray, 1979; Hine, 1951) reported by Shery (1987). It gives continuous intensity modulation, high spatial resolution, gives room to treat large field size, easy quality assurance (QA), shorter treatment time delivery with some drawbacks which are lack of automation (Chang, 2004), but there are some disadvantages like the therapist having to go to the treatment room to change the compensator in multiple fields and production cost, being labor intensive and time consuming. But now these drawbacks have been fixed in many developed countries by introducing a milling machine which is incorporated with the Treatment Planning System (TPS), and an automated compensator-IMRT technique (Javedan et al. 2008). Other main advantage of using cerrobend in this research are: its low melting point of 1580F (700C) which makes it easy to be recycled. It is readily available, inexpensive, high density (9.8g/cm3) and is used as shielding blocks in EBRT where doses are reduced by 95% or 99% of their initial value. As a material for compensation with high energy photons, cerrobend provides several advantages over tissue equivalent material (Shery, 1987). In the past, Cerrobend had not been considered as an excellent compensator material despite its high density. Recently Chang et al (2004) found that there are cerrobend filling techniques that produce smooth and accurate compensators with consistent density. Solidified Cerrobend in the compensator mold becomes one of the top choices of compensator material. And it can be easily shaped to the intended form with uniform density using the technique described by (Chang, 2004). Chang et al (2004) showed that compensator-IMRT technique has several benefits for delivering continuous intensity modulation and have shown that the finer resolution compensator-IMRT technique can also produce dosimetry that is closer to the ideal IMRT treatment (without any delivery limitation) compared with the segmental MLC IMRT technique. From this work the patients treated at the National Centre of Radiotherapy and Nuclear Medicine will benefit from all the advantages of IMRT techniques mentioned above. Consequently patients will also get a better and inexpensive treatment option.

National Institute of Business Management Essay

1. Describe the basic assumptions of Economics. 2. Discuss the vital functions of an economy. 3. Write an essay on the features of capitalist economy. 4. Explain the various assumptions on which all demand schedules are prepared. 5. Write an essay on Localization of Industries. 6. Describe the kinds of price elasticity of demand. 25 x 4=100 marks Answer of Question 1- Basic assumption of econimoics Economists have generally looked for some fundamental assumption about human behaviour from which most of the principles of economics can be ultimately deduced. Every decision maker in an economic systems-wheter he is a consument or producer, whethre is a house hold or a firm is assumed to have in a rational manner and go in for maximum gain. Economic rationality presupposed that every person knows his interest and selects that course of action, which promises him the greatest amount of statisfaction. The economists have, generally assumed that human beings are rational and that they are influenced by maximization principle for example every consumer is said to maximize his satisfaction with a given amount of expenditure, every producer maximizes his output and mizimizes his cost. Every seller minimizes his profit, as so on. But reationality and maximization principles are based on the further assumption of perfect knowledge, every rational consumenr for example knows  the differnent possiable alternative open to him and will choose that alrernative that promises maximum satisfaction. However, rationality is conditioned and influenced by habits and social. Habits acquired over a number of years influence the consumers in the choice of goods. Likewise, social customs infulence guide and modify economic behaviour of individuals. The assumption of economic rationality does not carry and moral or ethical implication. Rationality implies that is a period of acute shoratege, producers and distributors would raise the price and secure higher profit marigns. Such a behaivor may be condemned from the social point of view. But economically it is justified. At the same time, it is neccesasary to distinguish between individual rationality and social rationlaity. But from the social point of view, this may not be rational and proper, for bombay is already overcroweded with a high density of population, besides there are so many backward areas, which need industrialization from the social point of view it would have been better that the new factory is set up away from bombay, there is thus a possibility of clash between individual rationally and social rationalily. Anwer of Question no :- 2 Economy An economy refers to the financial system of the region, province or nation. â€Å"It is a system by which folks get a livelihood.† For instance the â€Å"Economy includes farms, factories, mines, shops, banks, roads, railways, aircrafts, offices, schools, cinemas etc., which grants the people with the goods and services which they also use themselves or sell overseas in order to be able to buy imports.† Sir John Hicks â€Å"An economy consists of nothing else but an enormous cooperation of workers or manufacturer to make things and do things which clients want.† The Vital Processes of An Economy Production, consumption and growth are vital factors of economics. Economies might differ in the organisation but all perform these three functions which  are discussed below. 1. Production -The First vital process of an economy is manufacture which must go on incessantly. â€Å"Production comprises any action, and the stipulation of any service, which satisfies and is likely to satisfy a want.† In this wider sense, production includes products produced on farms like rice, wheat, fruits and vegetables and those manufactured in the factories like clothes, electronic goods, electrical items etc. It also includes the services of shopkeepers, traders, transporters, actors, doctors, civil servants, teachers, engineers and akin to who help in fulfilling the needs of the people in the economy through their services. But production eliminates certain goods and services though they satisfy human needs. It includes, domestic work done within the family by the housewives, husband and children, production of hobby articles like paintings, production of vegetables in the kitchen garden. The last is voluntary work. John Hicks defines â€Å"Production is any acti vity directed to satisfaction of other people’s wants through exchange.† Thus production means exchange of goods for consideration of money. 2. Consumption -The second vital process of economy is consumption. It means the use of financial goods and services in the pleasure of human needs. The consumption that goes on in the fiscal may be of different types. Prof. Hicks organized it into two grouping – single-use goods and durable-use goods. Single goods are those which are used in a single act. Such goods are food stuffs, cigarettes, matches, fuel etc. durable use goods are those which can be used for a substantial period of time. It is unimportant whether the time is short or long. Such goods are pens, bicycles, clothes, fans, furniture etc. Prof. Brown defines as â€Å"For every kind of completed goods, in reality there is a kind of channel or rather a system of pipeline, elongating from the unique sources of resources used to the consumer.† The accretion of stock of such goods is called inventory investment. 3. Growth -Economic growth is â€Å"the process whereby the real per capita income of a country increases over a long period of time.† We itemise the factors which lead to the growth of an economy.† Growth of population predominantly  working population is the first cause of growth. A rapidly growing population in relation to the growth of the national product keeps the output per head at a low level. On the other hand, the enhancement in the productivity per head of developed economies like United States has been much higher because of their low rates of their national product. Technical acquaintance and development are the twin features in mounting productivity per head. Technical knowledge and development are autonomous It is technical knowledge which brings about new means of production, leads to innovation and growth of new equipment. The supply of savings is another factor that determines the growth rate of economy. Borrowing from abroad is another source of capital for the growth of economies. External borrowing is resorted to for two reasons. To supplement low domestic savings and to get foreign currency for the purpose of importing capital for development purposes. Thus all economies whether they are capitalist, socialist or mixed perform these important functions of production, consumption and growth. Central Problems of Economy There are five fundamental questions relating to the problem of economy and they are discussed below. 1. What to Produce and in What Quantities? To make a decision of what goods and services are to be created and the volume of productivity has to be determined and this is the first problem relating to economy. This involves allotment of scarce resources in relation to the composition of total productivity in the economy. Since resources are inadequate the society has to decide about the goods to be produced. If the society gives significance to the production of more consumption goods now, it will have less in future. A high precedence on capital goods implies consumer goods now and more in future. But since resources are inadequate, if some goods are produced in abundance, some other goods will have to be produced in smaller quantities. It will therefore have to choose among mixture which will give higher level of satisfaction. 2. How to Produce these goods? The next problem is how to fabricate these goods. That is the techniques and  methods to be applied in the production of the necessary goods. This problem is principally dependent on the accessibility of resources within the economy. If land is available in abundance, it may have widespread cultivation. If the labour is in abundance, it may use labour demanding techniques while in case of labour shortage, capital intensive techniques may be used. On the other hand easy consumer goods and small outputs necessitate small and less costly machines. Further it has to make a decision of what goods and services are to be created in the public sector and that in private sector. 3. For Whom are the Goods Produced? The third basic problem is for whom the goods and services are to be produced. That is the allotment of goods among the members of the society. The allotment of basic customer goods or supplies and lavish comforts and among the household takes place on the basis of among the allocation of country’s income. A rich person may have a large share of the lavish goods and a poor person may have more amounts of the basic consumer goods he needs. 4. How efficiently are the resources being utilised? This is one of the significant basic problems because of having made the three earlier decisions, the society has to see whether the capital it owns are being utilised fully or not. In case the resources of the financial system are lying idle. It has to find out ways and means to use them fully. If the idleness of resources, say man power, land or capital is due to their male allocation, the society has to adopt such monetary, fiscal or physical measures where this is corrected. In an economy where the available resources are being fully utilised, it is characterised by technical competence or full employment. To maintain it at this level, the economy must always be increasing the productivity of some goods and services by giving up something of others. 5. Is the Economy Growing? The last and the most imperative problem is to find out whether the economy is growing through time or is it sluggish. Economic growth takes place  through a superior rate of capital configuration which consists of restoring existing capital goods with new and more productive ones by adopting more well-organized production techniques or through modernization. Economic growth enables the economy to have more of both the goods. Answer of Question no: – 5 Manufacturing is the second largest type of production after primary production activity ‘of hunting, fishing, mining, lumbering, farming etc. Manufacturing has undergone a big change as a result of advancement of science and technology. From the making of few simple items, like hand made cloth, khandsari, mustard oil, agricultural implements etc. manufacturing to-day involves highly technical and complex machines, equipments and tools for the assembly of automobiles, ships, aircrafts, space ships, agricultural machines, computers and so on. For centuries, manufacturing had been a household work and items like agricultural implements; weapons etc. were produced on a small-scale. But with the increasing demand due to increase in population, it took the form of cottage industry and later, large scale manufacturing industries. Manufacturing is related to processing and altering the raw materials of agriculture, forests and that of minerals into finished or partially finished products. The agro raw materials which are transformed into finished products are cotton, wool, jute, sugarcane etc. and that of minerals are iron ore, copper, manganese, mica etc. Presently, the most important manufacturing industries are those which bring together manufactured items of different industries to make complicated machines and equipments required in means of transportation, agriculture, mining, military warfare etc. Development of industries is of utmost importance to man. In fact, their development is considered to be an index of a country’s economic prosperity and strength. The location of manufacturing industries depends upon a number of geographical and economic factors. These factors are known as factors of localization of industries or agglomeration of industries. The most important factors are: (i) Raw material. (ii) Source of Power. (iii) Labour. (iv) Means of transportation. (v) Market. (vi) Other factors like climate, Government Policies, capital, water, land etc. (i) Raw Material. Among the factors influencing location of an industry, close proximity to raw material availability of regular supply of cheap raw material are of utmost significance. Therefore, industries are set up close to or in the regions where raw material is available in plenty. This speaks for the localization of jute industry in West Bengal, Sugar industry in U.P and concentration of heavy industries in the states of Chattisgarh and West Bengal. If the raw material is heavy and of small value, the industries are set up in the regions of raw material. Iron smelting, brick making, cement manufacturing are best examples. Iron and Steel Plants at Jamshedpur (Jharkhand), Rourkela (Orissa), Bhilai (Chhattisgarh) and Durgapur (West Bengal) have been set up near the sources of raw material i.e., Iron ore. (ii) Source of Power. All types of manufacturing industries depend upon one or the other sources of power. It may be coal, oil, electricity, gas etc. In the industries, especially those of ferrous metallurgy, coal is the main source of power; therefore, these heavy industries are closely tied down to coal fields. The iron and steel industry of India in the Damodar Valley of Chattisgarh at Jamshedpur is located near the coal fields of Raniganj and Jharia. (iii) Labour. Modern industry requires large labour force, both skilled and unskilled. The availability of cheap labour in a region is an important factor determining the localization of industries. Different types of industries require different types of labour force. For example, watch-making, electronics, aeronautics, computers etc. require highly skilled labour, whereas, on the other hand, cotton textile manufacturing, sugar making, jute textile etc. employ more of unskilled labour. The development of the plantations in Assam and cotton textiles in Maharashtra are attributed to the availability of cheap efficient labour. In these regions it has also been seen that industrial centres tend to attract more industries, because plenty of labour is available in these centres, for example, Mumbai and Kolkata have become industrial cities of the country mainly because of availability of plenty of  labour in and around these mega cities. (iv) Means of Transportation. Industries depend upon efficient and cheap transportation system, which is essential for the movement of raw material as well as the finished products. They may be rail, road or water. Railway junctions are considered to be the most suitable sites for the localization of industries. These enjoy benefits of easy transportation from different directions. Similarly sea ports also develop as industrial centres because of availability of facilities of water transportation for export and import of products. (v) Market. Market is an important factor in determining localization of industries. Goods are manufactured to be sold in the market. Industries are generally set up close to urban centres. Sometimes, dense population may not prove to be solid market for the disposal of the different industrial products. If the people are poor, the purchasing capacity also becomes poor. In some of the Asian countries, where people are poor, industries which are engaged in the manufacturing of cheap and essential goods like coarse cloth find an adequate market. This explains why under-developed countries, though densely populated are poor in manufacturing industries. (vi) Other Factors. (a) Climate Climate also plays a part in the location of industries. The stimulating cool temperate climate is more suitable for the development of industries because this type of climate adds to the work efficiency of the labour force. This is one of the major reasons why temperate latitudes have well-developed manufacturing industries rather than the tropics or the desert or the Tundra regions. Climate plays a significant role in location of cotton textile manufacturing industries. The cool and humid climate helps in spinning of yarn and weaving of cloth processes. Development of film industry at Mumbai is due to favourable climate. (b)Capital. Development of industries requires a large capital investment. It may come from any source, local or foreign. Banks and other financial institutions play an important role in the growth of industries from time to time. (b) Government Policy. In order to give boost to industries in the country, the government gives certain guidelines, tax exemptions, electricity at concessional rates, subsidies, rail link etc., if these are set up as per government plan. Mohali, an industrial town near Chandigarh has come up on the industrial map of India because of Government policies. Thus Government Policy plays a significant role in determining place of location of an industry. If the Government bans import of foreign cars, the automobile industry is bound to flourish in that country. (d)Early Start. There is a tendency to set up new units in the area, where that industry is already much developed. It is because the area has been enjoying benefits of developed means of transport, financial institutions, banking facilities, availability of skilled labour and marketing ease. Hosiery industry got concentrated at Ludhiana can be cited as one example of role of early start. (e) Personal Preferences. Personal whims, prejudices of an entrepreneur and preferences also matter sometimes in the setting up of an industry in an area, ignoring all the economic and commercial considerations. In a democratic set up, sometimes political matters also initiate the establishment of certain heavy industries in certain regions. The setting of a Railway Coach Factory at Kapurthala in Punjab has been set up due to political interests rather than economic considerations. Construction of oil refinery at Bhatinda is another example of a political decision. Localization of industries at a place gives rise to a number of problems also. These are: (i) High cost of living. (ii) Shortage of living space. (iii) Sky high land prices. (iv) Traffic jams. (v) Pollution. (vi) Growth of slums. Some of the industries are highly localized in the country. These are due to combination of a number of geographical and socio-economic factors already discussed above. The examples are: 1. Sugar Manufacturing: U.P. and Bihar. 2. Jute Textiles: West Bengal. 3. Cotton Textiles: Maharashtra and Gujarat. 4. Cement Industry : M.P. and Rajasthan. 5. Iron and Steel: Jharkhand and Orissa. 6. Cinematography Mumbai 7. Leather goods: Kanpur, Agra. 8. Hosiery: Ludhiana. 9. Sports goods: Jalandhar. 10. Computers: Bangalore, Hyderabad, Gurgao Answer of Question no :- 6 Different types of Elasticity of Demand After knowing what is demand and what is law of demand, we can now come to elasticity of demand. Law of demand will tell you the direction i.e. it tells you which way the demand goes when the price changes. But the elasticity of demand tells you how much the demand will change with the change in price to demand to the change in any factor. Different types of Elasticity of Demand: 1. Price Elasticity of Demand 2. Income Elasticity of Demand 3. Cross Elasticity of Demand 4. Advertisement Elasticity of Demand 1. Price Elasticity of Demand: We will discuss how sensitive the change in demand is to the change in price. The measurement of this sensitivity in terms of percentage is called price Elasticity of Demand. According to Marshall, Price Elasticity of Demand is the degree of responsiveness of demand to the change in price of that commodity. Types of Price Elasticity of Demands: a) Perfectly Elastic b) Perfectly Inelastic c) Relatively Elastic d) Relatively Inelastic e) Unit Elasticity Factors influencing Price Elasticity of Demand: a) Nature of Commodity b) Availability of Substitutes c) Number of Uses d) Durability of commodity e) Consumer’s income Practical significance of Price Elasticity of Demand: a) Importance to the business b) Important to Government 2. Income elasticity of demand: In economics, the income elasticity of demand measures the responsiveness of the quantity demanded of a good to the change in the income of the people demanding the good. It is calculated as the ratio of the percent change in quantity demanded to the percent change in income. For example, if, in response to a 10% increase in income, the quantity of a good demanded increased by 20%, the income elasticity of demand would be 20%/10% = 2. 3. Cross elasticity of demand: In economics, the cross elasticity of demand and cross price elasticity of demand measures the responsiveness of the quantity demand of a good to a change in the price of another good. It is measured as the percentage change in quantity demanded for the first good that occurs in response to a percentage change in price of the second good. For example, if, in response to a 10% increase in the price of fuel, the quantity of new cars that are fuel inefficient demanded decreased by 20%, the cross elasticity of demand would be -20%/10% = -2. 4. Advertisement Elasticity of Demand: The degree of responsiveness of quantity demanded to the change in the advertisement expense of expenditure. Ea= Change in quantity demanded x original advertisement expenses Change in advertisement expenses original quantity demanded Important factors influencing Advertisement: 1. Promotional elasticity of demand will be affected, depending on whether it  is a new product or the product with a growing market. 2. The amount a competitor reacts to the firm’s advertisement. 3. The time interval between the advertisement expensed or expenditure and the unresponsiveness of the sales. 4. The influence of non-advertisement determinants of demands such as trends, price, income etc. Uses of Advertisement Elasticity of Demands: 1. It helps the manager to decide the advertisement expense. If the advertisement is more than one, which means incremental revenue exceeds incremental expenses, then increased expenditure on advertisement can be justified. 2. The fire should observe the saturation point, where advertisement pays nothing or does not help in increasing sales revenue

Blood bank management system Essay

1. Introductions BLOOD BANK MANAGEMENT is a software application to maintain day to day transactions in a blood bank. This software help to register all the donors, Blood collection details, blood issued details etc. Blood banks collect, store, and provide blood. Typically, these banks collect blood from voluntary blood donors. The banks then sort blood by type, check blood to  make sure it is free of disease and then store it for future use. The main mission of a blood bank is to provide life-saving blood to hospitals and other health care facilities. Blood cannot be created by any means, it can only be collected from the Humans i.e. donors. A blood bank is a bank of blood or blood components, gathered as a result of blood donation, stored and preserved for later use in blood transfusion..to satisfy blood necessity, to buy, sale and stock. 1.1 Purpose Online Blood Bank is aims serving for human welfare. We have all the information, you will ever need. Many people are here for you, to help you, willing to donate blood for you anytime. We have done the entire job, rest is yours. Search the blood group you need. You can help us by registering on Online Blood Bank if you are willing to donate your blood when needed. As a proud member of Blood Bank and a responsible human being, you can help someone in need. So donate blood in online. 1.2 Scope Blood Bank is aims serving for human welfare. We have all the information, you will ever need. Many people are here for you, to help you, willing to donate blood for you anytime. We have done the entire job, rest is yours. Search the blood group you need. You can help us by registering on Online Blood Bank if you are willing to donate your blood when needed. As a proud member of Online Blood Bank and a responsible human being, you can help someone in need. So donate blood in bank. In this project mainly 3 modules are there. 1. Admin 2. Donor 3. Acceptors 1. Admin: This module focuses on the both donors & acceptors. Each member in a donor & acceptor is given a user id and password, which identifies him  uniquely. The member is given a login form. he enters the login details user id and password. .. The options given to †¢ Maintain donor details †¢ Maintain referral once †¢ Update donor details †¢ View Experiences †¢ Logout Change Password Whenever a user wants to change his / her password he can select the change password option. The system displays the form, which asks him for his old password and new password. The system then compares the old password with the existing password in the database†¦ 2. Donor: Each member in a Donor is given a user id and password, which identifies him uniquely. The member is given a login form. he enters the login details user id and password. .. The options given to a each member in a staff are Change password Find a Blood group Why donate blood who needs blood Find a Donor Refer a friend Logout 3. Acceptor: In this you can store the information about Acceptors. Change password Find a blood group. Who needs blood Logout? Software requirements: Operating System: Windows XP Front End: NET (Active Server Pages, Visual basic ,Java Script) Back end : Sql Server Hardware requirements : MINIMUM P-IV SYSTEM 512 RAM 40 GB HDD 1.3Definitions Donor The person who donate the blood Accepter The person who accepts the blood Transfusion An act of transfusing donated blood, blood products, or other fluid into the circulatory system of a person or animal. 1.4References http://www.bharatbloodbank.com http://www.lionsbloodbank.net/ 1.5 Overview The first section tells about introduction of blood bank management system and its scope. The remaining sections of this document provide a general description, including characteristics of the users of this project, the product’s hardware, and the functional and data requirements of the product. General description of the project is discussed in section 2 of this document. Section 3 gives the functional requirements, data requirements and constraints and assumptions made while designing the E-Store. It also gives the user viewpoint of product. Section 3 also gives the specific requirements of the product. Section 3 also discusses the external interface requirements and gives detailed description of functional requirements. Section 4 is for supporting information. Now the description of SRS is follow:- Section 1. 1.Introduction 1.1 Purpose 1.2 Scope 1.3 Definitions 1.4 References 1.5 Overview Section 2. 2.Overall Description 2.1 Product Perspective 2.2 Product Functions 2.3 User Characteristics 2.4 Constraints Section 3. 3. Specific Requirements 3.1 External Interfaces 3.2 Functions 3.3 Performance Requirements 3.4 Logical Database Requirements 3.5 Design Constraints 3.6 Assumptions and Dependencies

Gun Violence in Schools - Free Essay Example

Sample details Pages: 2 Words: 558 Downloads: 8 Date added: 2019/03/20 Category Society Essay Level High school Tags: Gun Violence Essay School Shooting Essay Did you like this example? Guns Violence is a subject that has been brought to our attention due to media and political leaders. The problems still lays in our everyday life and the security of students is important. Whether it is correct for a teacher to have a weapon or not or having more security is what is being debated about. This a major issue within miles away from us. Gun Violence in schools can be prohibited by using mental health facilities, having officers properly trained and administrators establishing rules and regulations. One way to reduce to amount of gun violence in schools is by providing mental health services. In many situations, the person that obtains and uses the gun in a violent way has some sort has a mental health problem. Whether it be a voice telling them to do it or just because they truly do not see the harm they are doing, it can be completely prevented with a program or services of mental health. Due to media, we see it more often than it should happen especially near us. Most recently, there have been school shooting and threats in Universities such as Kennesaw State. The people involved had voices telling them to kill people which is not normal. Increasing access youth at risk and communities to proper mental health treatments can tremendously help (Examining School Safety and Gun Violence in America, 2014). If students do not find a sense of happiness at school, their mind can trigger violent actions. Schools are places connected to expectations of hope and refuge, friendship and r omance, and when these expectations are not met, it can cost a life (Warnick, 2015). Don’t waste time! Our writers will create an original "Gun Violence in Schools" essay for you Create order Having officers fully trained will eliminate many gun violence incidents as a whole. In many cases, officers on school campus are not fully trained to know what to do in every situation. For example, Georgia officers are trained how to use tasers and pepper spray before reaching for a gun. Many school officers are not put in many situations handling guns. When a rare situation occurs, it is a panicking moment in what to do. At Georgia Tech University, an officer did not know how to handle the situation properly and shot at the student and died. The university officer had not completed Crisis Intervention Team training offered by the GBI (Stirgus, 2018). These situations could be prevented by taking the time and money to fully train all officers on duty at schools, malls, and more. If the schools officers demand the same respect and standards as police officers, why cant they be held to the same accountability as them. School officers are to be treated legally as police officers, requ iring them to follow commonly accepted standards of police conduct in investigating crime in schools (Price, 2009). Gun Violence is not something a student should have to worry about going to school. Having that fear is a awful scare and can keep a student from focusing on his or her studies. This happens more often than it should and is closer to home each time. Sending your child to school should be a safe and welcoming environment to each individual. By training school officers, having mental health services and having school regulations, students can feel comfortable when attending classes. Big changes have to start somewhere and possibly Fulton county schools or universities can start making small advances.